Leptin regulation of neuronal excitability and cognitive function

Leptin regulation of neuronal morphology and hippocampal synaptic function

The central actions of the hormone leptin in regulating energy homeostasis via the hypothalamus are well documented. However, evidence is growing that this hormone can also modify the structure and function of synapses throughout the CNS. The hippocampus is a region of the forebrain that plays a crucial role in associative learning and memory and is an area also highly vulnerable to neurodegene...

P3: Neuronal Death Following Posttraumatic Excitability and Seizure

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Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure

Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...

Allostatic regulation of neuronal excitability by transient ischemia.

During development and learning, a neuron actively maintains a stable state of excitability by adjusting the strength of its synaptic inputs (Turrigiano and Nelson, 2004). This homeostatic synaptic plasticity ensures that a neuron maintains a set-point spike firing rate when the overall synaptic input is increasing or decreasing (Turrigiano, 2008). Beside this homeostatic synaptic plasticity, n...

BC 1 Regulation of mGluR - Mediated Neuronal Excitability